PNOE

PNOĒ, founded in 2016 by two Greek engineers, develops clinical-grade portable metabolic breath analysis systems. The company's stated aim is to bring lab-standard cardio-metabolic diagnostics to a mass market, allowing health professionals to prescribe nutrition and exercise on the basis of biomarker data rather than guesswork. Nearly two years of research and development preceded its first commercial product; the work traces back to PhD research by one of the founders. PNOĒ is backed by Y Combinator and affiliated with Endeavor.

Its principal product, the PNOĒ Breath Analysis System, is described as the first commercial portable system to deliver lab-grade cardio-metabolic analysis, offering a 360° view of human physiology without blood draws or other invasive procedures. The underlying technology measures 23 biomarkers in a single breath test, yielding physiological metrics including VO2 Max, resting metabolic rate, fat burn efficiency and biological age. Technical work spans breath and metabolic analysis, portable sensing hardware and physiological biomarker measurement.

PNOĒ operates in health and fitness, wellness optimisation and clinical diagnostics. Its technology is used by fitness clubs (Equinox), hospitality groups (Four Seasons) and elite sport (Red Bull Racing). The company has a presence in the United States and Greece and serves health professionals globally. It has been named by the Financial Times among America's fastest-growing companies.

The company describes itself as mission-driven and research-intensive, with a stated goal of democratising access to breath analysis and metabolic health diagnostics and a focus on non-invasive, clinically grounded measurement - summarised internally as "nutrition and exercise as medicine".