OrganOx

OrganOx is a medical device company that develops normothermic machine perfusion technology, which keeps donor organs alive and functioning outside the body. Its systems circulate oxygenated blood and nutrients through organs at body temperature, allowing clinicians to preserve, assess and transplant them rather than store them on ice. The company was founded in 2008 as a University of Oxford spin-out by Peter Friend, a transplant surgeon, and Constantin Coussios, a biomedical engineer, and is based in Oxford.

Its principal product, metra®, is described as the world's first normothermic machine perfusion device. It maintains donor livers at body temperature and enables real-time assessment of organ function before transplantation. OrganOx reports that the device has supported more than 6,000 liver transplants worldwide and has enabled the use of organs previously judged unsuitable, contributing to reductions in organ discard rates.

The company's work spans normothermic machine perfusion, organ preservation, biomedical engineering, transplantation medicine and organ viability assessment. It reports 17 years of research and development and won the 2025 MacRobert Award, the UK's top prize for engineering innovation. In 2025 OrganOx was acquired by Terumo Corporation in a deal valued at $1.5 billion. Its technology is deployed globally.