Description
Title: Bioanalytical Associate Scientist
Marengo Therapeutics is pioneering first-in-class therapeutics that activate the right immune response to promote lifelong protection against cancer. Marengo has uncovered a novel approach to T cell activation by targeting the Vß TCR chain to unleash rapid, potent, and long-lasting anti-tumor immune responses safely and effectively. We’re leveraging our versatile, proprietary bispecific fusion protein platform to selectively deliver the right activation to the right T cell subsets, customizable to patient needs with its tunable properties, with an initial focus on advanced solid tumors and broad applicability beyond.
Marengo is driven by core values that guide our company’s mission and approach from the inside out: we demonstrate an unparalleled commitment to patients and their loved ones, we are confident in our science and our team, we operate with courage, and we creatively apply deep expertise to new ways of thinking with curiosity and imagination. With an exciting journey ahead and a tremendous opportunity for growth, now is the time to join the Marengo team and impact cancer patient care – are you ready to join the new frontier?
To learn more, visit marengotx.com
Role: Bioanalytical Associate Scientist
Overview: Marengo is seeking an exceptional Associate Scientist to join our team. Reporting to the translational science lead, this individual will contribute significantly to a small, rapidly expanding company offering opportunity to advance while improving the lives of patients.
Please: local candidates only. This is a full-time, in-the-lab/office role.
Purpose Of The Role
- The ideal candidate will be a key member of a growing bioanalytical and pharmacology group providing bespoke assay and drug metabolism/distribution and pharmacokinetics (DMPK) support from early lead optimization through to Phase 1 trials in patients.
- Initially, this role will focus on supporting projects advancing molecules from early lead optimization stages through to therapeutic candidate nomination by supporting PK, PD, immunogenicity, and exploratory toxicological assessments in relevant animal models.
- The successful candidate will lead the development of novel assays to support early understanding of quantitative pharmacology in preclinical species to support advancing our novel lead molecules. This will include designing assays from scratch and considering and evaluating optimal platforms, validating assays according to good scientific practice, and running samples from studies. The successful candidate will also be capable of analyzing pharmacokinetic data and providing basic interpretation, with the opportunity to significantly develop these skills with other pharmacometrics experts and consultants.
Who are we looking for?
- An energetic and passionate scientist who can lead the development and validation of novel assays to measure the disposition and pharmacokinetics (PK) of multi-specific therapeutics in preclinical species, using various biological samples from mostly non-clinical studies.
What are we looking for?
- The ideal candidate will have a bachelor’s degree in life sciences or a related scientific discipline with 3-5 years or a Master’s degree with 2-5 years experience.
- Individuals with strong technical expertise and direct experience in a variety of bioanalytical methods (ELISA, ECLIA, RIA) using different immunological and biochemical platforms, such as MSD, Gyros, Singulex or other platforms and familiarity with any automation platforms are preferred
- The candidate must be able to work with human and animal blood, serum, plasma and tissue specimens.
- A background in pharmacology or drug metabolism or prior industry experience is preferred, preferably in an immunoassay development or DMPK setting.
- Experience with basic analysis, manipulation, and interpretation of drug pharmacokinetic data in preclinical studies (particularly with biopharmaceuticals) is also desirable.
- Candidates must have an excellent record keeping, communication skills, and be able to routinely independently summarize findings via oral presentation to a peer group or written report.
- Working knowledge of or experience with electronic laboratory notebooks and electronic inventory software
- Candidates should demonstrate the ability to multi-task the ability to work under tight timelines with a sense of urgency in a dynamic multi-disciplinary team environment.
Requirements
What are we offering?
- Membership within a growing, CARING, and collegial organization
- Highly intellectual and analytical team, that challenges the status quo and loves innovation
- Being part of a passionate, involved, and cutting-edge Research Team
- Exposure to pioneering science and the discovery of drugs to help treat patients with cancer
Responsibilities
- Lead the development and validation of novel assays to measure the disposition and pharmacokinetics (PK) of multi-specific therapeutics in preclinical species, using various biological samples from mostly non-clinical studies.
- Responsibility for developing high-quality assays to support the assessment of pharmacodynamics and /immunogenicity of novel multi-specific therapeutics.
- Analyze and interpret various types of bioanalytical data, and author and/or review assay and in vivo study protocols and reports
- Additional responsibilities will include assay troubleshooting, development of new technology platforms, and assay automation
- Managing technology transfer of immunogenicity and PK methods and related bioanalytical activities to CROs including writing and/or review of SOPs.
- Opportunity to contribute to early PK modelling and human PK/PD simulation with other functions and external consultants
Education And Experience
- The ideal candidate will have a bachelor’s degree in life sciences or a related scientific discipline with 3-5 years or a Master’s degree with 2-4 years experience.
- Individuals with strong technical expertise and direct experience in a variety of bioanalytical methods (ELISA, ECLIA, RIA) using different immunological and biochemical platforms, such as MSD, Gyros, Singulex or other platforms and familiarity with any automation platforms are preferred
- The candidate must be able to work with human and animal blood, serum, plasma and tissue specimens.
- A background in pharmacology or drug metabolism or prior industry experience is preferred, preferably in an immunoassay development or DMPK setting.
- Experience with basic analysis, manipulation, and interpretation of drug pharmacokinetic data in preclinical studies (particularly with biopharmaceuticals) is also desirable.
- Candidates must have an excellent record keeping, communication skills, and be able to routinely independently summarize findings via oral presentation to a peer group or written report.
- Working knowledge of or experience with electronic laboratory notebooks and electronic inventory software
- Candidates should demonstrate the ability to multi-task the ability to work under tight timelines with a sense of urgency in a dynamic multi-disciplinary team environment.
Competencies
Adaptability: Responds resourcefully, flexibly, and positively when faced with new challenges, transitions, and demands. Willingly and effectively deals with the stress and complexities of various situations. Moves forward productively and optimistically under conditions of change and uncertainty.
Collaboration: Embodies and promotes collaboration and works effectively with others across the organization to achieve goals. Demonstrates proficient cross-company communication, cultural sensitivity, and partnership in interactions with others. Involves others in decisions and plans and credits them for their contributions and accomplishments.
Execution: Drives execution of strategic and operating plans while maintaining operational effectiveness. Conveys a strong sense of urgency around continuous improvement, achieving high quality results, and accelerating business performance. Addresses problems directly and drives
changes necessary to achieve business objectives.
Relationship Building: Establishes and maintains strong relationships internally and externally. Respects and relates well to management, colleagues, peers, and direct reports. Champions a culture of respect, diversity, and inclusion that values and respects individuals. Earns the respect of others through principled leadership, sound business ethics, and authenticity.
Location: Cambridge, MA ( We are located in Lower Cambridge, called Cambridgeport)
When You Join Marengo, You Will Have
In addition to the compensation, we offer the following benefits:
- Free parking, Cambridge location reachable by public transportation (Red Line)
- Customized and competitive health coverage, including medical offered through BCBS (HMO/PPO), dental, and vision
- Flexible Spending Accounts for medical and dependent care expenses
- Eligible from the first day for 401K, no matching
- A robust package of Marengo-paid insurance coverage, including life insurance, short-term and long-term disability, and parental leave
- 20 days of vacation and one personal day, and 64 hours of sick time per year, in addition to 16 company holidays
TO ALL AGENCIES:
Please, no phone calls or emails to any employee of Marengo about our openings. All resumes submitted by search firms/employment agencies to any employee at Marengo via email, the internet or in any form and/or method will be deemed the sole property of Marengo unless such search firms/employment agencies were engaged by Marengo for this position and a valid agreement with Marengo is in place. In the event a candidate who was submitted outside of the Marengo agency engagement process is hired, no fee or payment of any kind will be paid.
Marengo Therapeutics, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.
